Evaluation and Management of Congenital Chagas Disease in the United States

Author:

Edwards Morven S1,Stimpert Kelly K23,Bialek Stephanie R3,Montgomery Susan P3

Affiliation:

1. Department of Pediatrics, Baylor College of Medicine, Houston, Texas

2. IHRC, Inc, Atlanta, Georgia

3. Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia

Abstract

Abstract Chagas disease is underappreciated as a health concern in the United States. Approximately 40 000 women of childbearing age living in the United States have chronic Chagas disease. Most of them are unaware that they have an infection that is transmissible to their offspring. The estimated US maternal-to-infant transmission rate of Trypanosoma cruzi is 1% to 5%. Ten percent to 40% of neonates with congenital T cruzi infection have clinical signs consistent with a congenital infection but no findings are unique to Chagas disease. If left untreated, 20% to 40% of infants with Chagas disease will later develop potentially fatal cardiac manifestations. Molecular testing can confirm the diagnosis in neonates. Treatment is well tolerated in infancy and usually results in cure. Screening of at-risk women during pregnancy can identify maternal infection and allow early assessment and treatment for congenital T cruzi infection.

Funder

Centers for Disease Control and Prevention Cooperative

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology, and Child Health

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