Stool Toxin Concentration Does Not Distinguish <i>Clostridioides difficile</i> Infection from Colonization in Children Less Than 3 Years of Age-Reference-Cited by-同舟云学术

Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age

Published:2022-07-08 Issue:10 Volume:11 Page:454-458
ISSN:2048-7207
Container-title:Journal of the Pediatric Infectious Diseases Society
language:en
Short-container-title:

Author:

Sandora Thomas J¹^ORCID,Williams David N²,Daugherty Kaitlyn³^ORCID,Geer Christine²³,Cuddemi Christine³,Kociolek Larry K⁴,Chen Xinhua³,Xu Hua³,Savage Timothy J¹^ORCID,Banz Alice⁵,Garey Kevin W⁶,Gonzales-Luna Anne J⁶^ORCID,Kelly Ciarán P³,Pollock Nira R⁷⁸^ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Pediatrics, Boston Children’s Hospital, Harvard Medical School , Boston, Massachusetts , USA

2. Institutional Centers for Clinical and Translational Research, Boston Children’s Hospital , Boston, Massachusetts , USA

3. Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts , USA

4. Division of Infectious Diseases, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine , Chicago, Illinois , USA

5. bioMerieux , Marcy L’Etoile , France

6. Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy , Houston, Texas , USA

7. Department of Laboratory Medicine, Boston Children’s Hospital, Harvard Medical School , Boston, Massachusetts , USA

8. Division of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts , USA

Abstract

Abstract In a prospective cohort study, stools from children <3 years with and without diarrhea who were Clostridioides difficile nucleic acid amplification test-positive underwent ultrasensitive and quantitative toxin measurement. Among 37 cases and 46 controls, toxin concentration distributions overlapped substantially. Toxin concentration alone does not distinguish C. difficile infection from colonization in young children.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

Link

https://academic.oup.com/jpids/article-pdf/11/10/454/46621589/piac059.pdf

Reference15 articles.

1. Antibiotic resistance threats in the United States, 2019

2. Attributable cost of Clostridium difficile infection in pediatric patients.;Mehrotra;Infect Control Hosp Epidemiol,2017