Increasing Clindamycin and Trimethoprim-Sulfamethoxazole Resistance in Pediatric Staphylococcus aureus Infections

Author:

Khamash Dina F1,Voskertchian Annie1,Tamma Pranita D1,Akinboyo Ibukunoluwa C1,Carroll Karen C2,Milstone Aaron M13

Affiliation:

1. Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland

2. Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland

3. Department of Hospital Epidemiology and Infection Control, Johns Hopkins Hospital, Baltimore, Maryland

Abstract

Abstract The epidemiology of Staphylococcus aureus infection in children is dynamic. We conducted a retrospective observational study on pediatric clinical cultures, performed between 2005 and 2017, that grew S aureus to determine temporal trends in antibiotic resistance. Although methicillin resistance declined, clindamycin and trimethoprim-sulfamethoxazole resistance increased significantly, especially among community-onset isolates.

Funder

Agency for Healthcare Research and Quality

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

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