Clinical Manifestations and Bacterial Genomic Analysis of Group A Streptococcus Strains That Cause Pediatric Toxic Shock Syndrome-Reference-Cited by-同舟云学术

Clinical Manifestations and Bacterial Genomic Analysis of Group A Streptococcus Strains That Cause Pediatric Toxic Shock Syndrome

Published:2018-07-31 Issue:3 Volume:8 Page:265-268
ISSN:2048-7207
Container-title:Journal of the Pediatric Infectious Diseases Society
language:en
Short-container-title:

Author:

Deniskin Roman¹,Shah Brittany²,Muñoz Flor M¹³,Flores Anthony R²

Affiliation:

1. Department of Pediatrics, Baylor College of Medicine and Texas Children’s Hospital, Houston

2. Division of Infectious Diseases, Department of Pediatrics, Center for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Sciences Center at Houston

3. Section of Infectious Diseases, Baylor College of Medicine and Texas Children’s Hospital, Houston

Abstract

Abstract We report here 18 cases of pediatric group A streptococcal toxic shock syndrome, associated clinical findings, and bacterial molecular genetic characteristics discovered through whole-genome sequencing. This comparative whole-genome sequencing revealed unique gene content (speK) and polymorphisms (dpiB) in emm87 group A Streptococcus, the relative contributions of which, in combination with the host response, in the development of streptococcal toxic shock syndrome remain to be elucidated.

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

Link

http://academic.oup.com/jpids/article-pdf/8/3/265/30125173/piy069.pdf

Reference12 articles.

1. The global burden of group A streptococcal diseases;Carapetis;Lancet Infect Dis,2005

2. Epidemiology of invasive group A streptococcal infections in the United States, 2005–2012;Nelson;Clin Infect Dis,2016

3. Cluster of fatal group A streptococcal emm87 infections in a single family: molecular basis for invasion and transmission;Flores;J Infect Dis,2017