T-Cell Responses Against <i>Mycobacterium ulcerans</i> and <i>Mycobacterium tuberculosis</i> Protein Extracts Identify Children With Buruli Ulcer Disease-Reference-Cited by-同舟云学术

T-Cell Responses Against Mycobacterium ulcerans and Mycobacterium tuberculosis Protein Extracts Identify Children With Buruli Ulcer Disease

Published:2022-09-07 Issue:12 Volume:11 Page:575-577
ISSN:2048-7207
Container-title:Journal of the Pediatric Infectious Diseases Society
language:en
Short-container-title:

Author:

Jacobsen Marc¹,Adjei Jonathan Kofi²,Aniagyei Wilfred²,Adankwah Ernest²³,Seyfarth Julia¹,Mayatepek Ertan¹,Antwi-Berko Daniel²,Sakyi Samuel Asamoah⁴,Debrah Alexander Y²,Debrah Linda Batsa²,Owusu Dorcas O²,Phillips Richard O²⁵

Affiliation:

1. Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University , Düsseldorf , Germany

2. Kumasi Centre for Collaborative Research in Tropical Medicine , Kumasi , Ghana

3. Department of Medical Diagnostics, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST) , Kumasi , Ghana

4. Department of Molecular Medicine, School of Medicine and Dentistry, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST) , Kumasi , Ghana

5. Department of Medicine, School of Medicine and Dentistry, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST) , Kumasi , Ghana

Abstract

Abstract Immune-based diagnosis of Buruli ulcer disease (BUD) in children is difficult due to cross-reactivity between mycobacteria. We found that T-cell IFNγ/TNFα responses against Mycobacterium (M.) ulcerans and M. tuberculosis (PPDMulc, PPDMtub) were different between children with BUD (n = 27) and TB (n = 20) but only ratios (PPDMtub/PPDMulc) discriminated the study groups efficiently.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

Link

https://academic.oup.com/jpids/advance-article-pdf/doi/10.1093/jpids/piac092/46325449/piac092.pdf

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