Immunogenicity, Immunological Memory and Monitoring of Disease Activity Following an Anamnestic Immunization With the 13-Valent Pneumococcal Conjugate Vaccine in Children With Idiopathic Nephrotic Syndrome-Reference-Cited by-同舟云学术

Immunogenicity, Immunological Memory and Monitoring of Disease Activity Following an Anamnestic Immunization With the 13-Valent Pneumococcal Conjugate Vaccine in Children With Idiopathic Nephrotic Syndrome

Published:2024-06-03 Issue:7 Volume:13 Page:363-367
ISSN:2048-7207
Container-title:Journal of the Pediatric Infectious Diseases Society
language:en
Short-container-title:

Author:

Kitsou Konstantina¹,Askiti Varvara²,Tzanoudaki Marianna³,Mitsioni Andromachi²,Papadatou Ioanna¹,Liatsis Emmanouil³,Kanaka-Gantenbein Christina⁴,Magiorkinis Gkikas⁵^ORCID,Spoulou Vana¹

Affiliation:

1. Immunobiology and Vaccinology Research Laboratory, First Department of Pediatrics, “Aghia Sophia” Children’s Hospital, School of Medicine, National and Kapodistrian University of Athens , Athens , Greece

2. Department of Nephrology, “P. and A. Kyriakou” Children’s Hospital , Athens , Greece

3. Department of Immunology and Histocompatibility, Specific Reference Centre for Primary Immunodeficiencies-Paediatric Immunology, “Aghia Sophia” Children’s Hospital , Athens , Greece

4. Division of Endocrinology, Diabetes and Metabolism, First Department of Pediatrics, Medical School, Aghia Sophia Children’s Hospital, National and Kapodistrian University of Athens , Athens , Greece

5. Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens , Athens , Greece

Abstract

Abstract Anamnestic 13-valent pneumococcal conjugate vaccine immunization did not affect the relapse risk in pediatric idiopathic nephrotic syndrome. Pneumococcal serotype (PS)-specific antibody titers increased significantly in all groups. Children receiving immunomodulatory treatments (IMTs) displayed significantly lower levels of PS-specific antibodies for 3/8 serotypes tested. PS-specific B-cell counts significantly increased only in healthy controls and patients receiving corticosteroids.

Funder

European Society for Paediatric Infectious Diseases

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/jpids/advance-article-pdf/doi/10.1093/jpids/piae057/58064150/piae057.pdf

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