Outcomes of Human Adenovirus Infection and Disease in a Retrospective Cohort of Pediatric Hematopoietic Cell Transplant Recipients

Author:

Fisher Brian T1234,Boge Craig L K12,Petersen Hans5,Seif Alix E36,Bryan Matthew234,Hodinka Richard L7,Cardenas Ana Maria89,Purdy Dale R2,Loudon Brandon6,Kajon Adriana E5

Affiliation:

1. Division of Infectious Diseases, Pennsylvania

2. Center for Pediatric Clinical Effectiveness, Pennsylvania

3. Infectious Disease Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico

4. Division of Oncology, Pennsylvania

5. Infectious Disease Diagnostics Laboratory, Children’s Hospital of Philadelphia, Pennsylvania

6. Department of Pediatrics, Philadelphia

7. Department of Pathology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia

8. Center for Clinical Epidemiology and Biostatistics, Philadelphia

9. Department of Biomedical Sciences, University of South Carolina School of Medicine Greenville, Greenville Health System

Abstract

Human adenoviruses were commonly detected in this cohort of pediatric patients undergoing hematopoietic cell transplantation, and the case-fatality rate in allogeneic transplant recipients was high (25.9%). Preemptive cidofovir therapy was not associated with a reduction in the progression to human adenovirus disease.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

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