Change in Bacterial Causes of Community-Acquired Parapneumonic Effusion and Pleural Empyema in Children 6 Years After 13-Valent Pneumococcal Conjugate Vaccine Implementation

Author:

Madhi Fouad12,Levy Corinne234ORCID,Morin Laurence5,Minodier Philippe6,Dubos François7,Zenkhri Ferielle8,Dommergues Marie Aliette9,Mezgueldi Ellia10,Levieux Karine11,Aurel Marie,Launay Elise,Biscardi Sandra,Hees Laure,Craiu Irina,Gillet Yves,Guen Christele Gras-Le,Hau Isabelle,Lorrot Mathie,Martinot Alain,Angoulvant François,Béchet Stéphane234,Varon Emmanuelle12,Cohen Robert23413,Madhi Fouad,Levy Corinne,Morin Laurence,Minodier Philippe,Dubos François,Zenkhri Ferielle,Dommergues Marie Aliette,Mezgueldi Ellia,Levieux Karine,Varon Emmanuelle,Cohen Robert, ,

Affiliation:

1. Service de Pédiatrie, Centre Hospitalier Intercommunal, Créteil, France

2. Université Paris Est, IMRB-GRC GEMINI, Créteil, France

3. ACTIV, Pediatric Clinical and Therapeutical Association of the Val de Marne, Saint-Maur des Fossés, France

4. Clinical Research Center, Centre Hospitalier Intercommunal de Créteil, France

5. Department of General Pediatrics, AP-HP, Hôpital Robert Debré, Université Paris Diderot, France

6. Department of Pediatric Emergency, CHU Nord, Marseille, France

7. Pediatric Emergency Unit and Infectious Diseases, University of Lille, CHU Lille, France

8. Department of Pediatric Emergency, AP-HP, Hôpital Le Kremlin-Bicêtre, Université Paris Sud, Bicêtre, France

9. Department of General Pediatrics, Centre Hospitalier de Versailles, Le Chesnay, France

10. Department of Pediatric Emergency, HFME Lyon, France

11. Department of Pediatrics, CHU Nantes, France

12. National Reference Center for Pneumococci, Laboratoire de Microbiologie, AP-HP, Hopital Européen Georges-Pompidou, Paris, France

13. Unité Court Séjour, Petits Nourrissons, Service de Néonatologie, Centre Hospitalier Intercommunal de Créteil, France

Abstract

AbstractWe describe here changes in the bacterial causes of pleural empyema before and after implementation of the 13-valent pneumococcal conjugate vaccine (PCV13) program in France (2009–2017). For 220 (39.3%) of 560 children, a bacterial cause was found. The frequency of pneumococcal infection decreased during the study from 79.1% in 2009 to 36.4% in 2017 (P < .001). Group A streptococcus is now the leading cause of documented empyema (45.5%).

Funder

Pfizer Pharmaceuticals

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

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