First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia-Reference-Cited by-同舟云学术

First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia

Published:2023-10-16 Issue:11 Volume:12 Page:581-585
ISSN:2048-7207
Container-title:Journal of the Pediatric Infectious Diseases Society
language:en
Short-container-title:

Author:

Chabala Chishala¹²³,Jacobs Tom G⁴^ORCID,Moraleda Cinta⁵,Ndaferankhande John M⁶,Mumbiro Vivian⁷,Passanduca Alfeu⁸,Namuziya Natasha²,Nalwanga Damalie⁹,Musiime Victor⁹¹⁰,Ballesteros Alvaro⁵,Domínguez-Rodríguez Sara⁵^ORCID,Chitsamatanga Moses⁷,Cassia Uneisse⁸,Nduna Bwendo¹¹,Bramugy Justina¹²,Sacarlal Jahit⁸,Madrid Lola⁵¹³,Nathoo Kusum J⁷,Colbers Angela⁴^ORCID,Burger David M⁴,Mulenga Veronica¹²,Buck W Chris⁸¹⁴,Mujuru Hilda A⁷,te Brake Lindsey H M⁴,Rojo Pablo⁵¹⁵¹⁶,Tagarro Alfredo⁵¹⁷¹⁸^ORCID,Aarnoutse Rob E⁴,Sidat Muhammad,Manjate Elias,Martins Sónia,Langa Stella,Nipaco Natália,Machava Sara,Chirindza Anastância,Martins Luzidina,Nhaca Mércia,Nathoo Kusum J,Chitsamatanga Moses,Marange Ruth,Mudzingwa Shepherd,Murungu Dorothy,Zulu Idah,Shankalala Perfect,Mukubesa Mulima,Namwinwa Juliet,Chibuye Chalwe,Chipoya Terence,Simunyola Bwalya,Tembo John,Inambao Muleya,Chitondo Salome,Mumba Wyclef,Mankushe Endreen,Musukwa Henry,Sondashi Davies,Kamugisha Albert,Econi Karen,Kiggwe Andrew,Beinomugisha Judith,Nkinzi Sharafat,Kakooza Lawrence,Namisanvu Henriator,Lajara Mark Nancy,Mwesige Josam Thembo,Segawa Ivan,Ssessanga Joseph,Mbavu Paul,Kafufu Bosco,Nansera Denis,Najjingo Elizabeth,Mbabazi Bashira T,Lugemwa Abbas,Kasozi Mariam,Ankunda Rogers,Manukyan Lilit,

Affiliation:

1. University of Zambia, School of Medicine , Lusaka , Zambia

2. University Teaching Hospital, Children’s Hospital , Lusaka , Zambia

3. HerpeZ , Lusaka , Zambia

4. Department of Pharmacy, Radboudumc Institute for Medical Innovation (RIMI), Radboud University Medical Center , Nijmegen , The Netherlands

5. Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O) , Madrid , Spain

6. Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Kamuzu University of Health Sciences , Blantyre , Malawi

7. University of Zimbabwe Clinical Research Centre , Harare , Zimbabwe

8. Universidade Eduardo Mondlane, Faculdade de Medicina , Maputo , Mozambique

9. Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University , Kampala , Uganda

10. Joint Clinical Research Centre , Kampala , Uganda

11. Arthur Davidson Children’s Hospital , Ndola , Zambia

12. Centro de Investigação em Saúde de Manhiça , Maputo , Mozambique

13. London School of Hygiene and Tropical Medicine (LMC) , London , UK

14. University of California Los Angeles, David Geffen School of Medicine , Los Angeles, California , USA

15. Complutense University of Madrid , Madrid , Spain

16. Pediatric Service, Hospital Universitario 12 de Octubre, Servicio Madrileño de Salud (SERMAS) , Madrid , Spain

17. Pediatric Service, Infanta Sofia University Hospital, Servicio Madrileño de Salud (SERMAS) , Madrid , Spain

18. Universidad Europea de Madrid , Madrid , Spain

Abstract

Abstract Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased doses of first-line TB drugs in infants.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

Link

https://academic.oup.com/jpids/advance-article-pdf/doi/10.1093/jpids/piad088/52174474/piad088.pdf

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