“An Extra Variable to Consider”—Vaccine-Induced Seropositivity and Adolescent HIV Vaccine Clinical Trials

Author:

Fatola Omolayo1,Corneli Amy23,Perry Brian2,Hanlen-Rosado Emily2,Nsonwu Adora2,Constantine Evangelia P4,Thompson Amelia B567

Affiliation:

1. Indiana University School of Medicine , Indianapolis, Indiana , USA

2. Department of Population Health Sciences, Duke University School of Medicine , Durham, North Carolina , USA

3. Duke Clinical Research Institute, Duke University School of Medicine , Durham, North Carolina , USA

4. Dartmouth College , Hanover, New Hampshire , USA

5. Duke Human Vaccine Institute, Duke University School of Medicine , Durham, North Carolina , USA

6. Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine , Durham, North Carolina , USA

7. Department of Pediatrics, Division of Infectious Diseases, AdventHealth for Children , Orlando, Florida , USA

Abstract

Abstract Our study explores the understanding of vaccine-induced seropositivity (VISP) and its potential impact on US adolescents’ and caregivers’ willingness to participate in adolescent HIV vaccine clinical trials. Findings from in-depth interviews suggest that addressing concerns about VISP will be essential for future pediatric HIV vaccine trials in the United States.

Funder

National Institute of Allergy and Infectious Diseases

U.S. Public Health Service

HVTN Research and Mentorship Program

Duke University Center for AIDS Research

NIH

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

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