Breadth and Dynamics of Human Norovirus-Specific Antibodies in the First Year of Life

Author:

Vielot Nadja A1,Brinkman Amanda2,DeMaso Christina2ORCID,Vilchez Samuel3,Lindesmith Lisa C4,Bucardo Filemon3,Reyes Yaoska3,Baric Ralph S4,Ryan Elizabeth P5,Braun Ralph2,Becker-Dreps Sylvia14

Affiliation:

1. Department of Family Medicine, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina , USA

2. Takeda Vaccines, Inc. , Cambridge, Massachusetts , USA

3. Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua , León, León , Nicaragua

4. Department of Epidemiology, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina , USA

5. Department of Environmental and Radiological Health Sciences, Colorado State University , Fort Collins, Colorado , USA

Abstract

Abstract We measured antibody binding to diverse norovirus virus-like particles over 12 months in 16 children. All had maternal antibodies at 2 months, with estimated lowest levels at 5 months of age. Antibody increases after 3 months suggested natural infections. This information could guide the timing of future norovirus vaccines.

Funder

Fogarty International Center

National Institute of Allergy and Infectious Diseases

National Institute of Allergy and Infectious Disease

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

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