Fetal Transfer of Human Metapneumovirus-Neutralizing Antibodies Is Reduced From Mothers Living With HIV-1-Reference-Cited by-同舟云学术

Fetal Transfer of Human Metapneumovirus-Neutralizing Antibodies Is Reduced From Mothers Living With HIV-1

Published:2022-04-07 Issue:7 Volume:11 Page:341-344
ISSN:2048-7207
Container-title:Journal of the Pediatric Infectious Diseases Society
language:en
Short-container-title:

Author:

Ramocha Lesego M¹²,van den Hoogen Bernadette G³,Baillie Vicky¹²⁴,van Nieuwkoop Stefan³,Cutland Clare L⁴,Jones Stephanie¹²,Moultrie Andrew¹²,Izu Alane¹²⁴,Verwey Charl¹⁵,Madhi Shabir A¹²⁴,Dorfman Jeffrey R¹²⁴⁶^ORCID

Affiliation:

1. South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg , South Africa

2. Department of Science/National Research Foundation: Vaccine Preventable Diseases, University of the Witwatersrand, Faculty of Health Science , Johannesburg , South Africa

3. Department of Viroscience, Erasmus University Medical Centre , Rotterdam , the Netherlands

4. African Leadership in Vaccinology Expertise (ALIVE), Faculty of Health Sciences, University of the Witwatersrand , Johannesburg , South Africa

5. Department of Pediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg , South Africa

6. Division of Medical Virology, Department of Pathology, Stellenbosch University , Cape Town , South Africa

Abstract

Abstract Transplacental hMPV-neutralizing antibody transfer was reduced from mothers living with HIV-1. However, a comparison of antibody titers at birth between hMPV hospitalization cases at <6 months and matched controls suggested that reduced maternal antibody might not be the primary cause of the previously reported elevated hMPV risk in HIV-1-exposed infants.

Funder

South African Research Chairs Initiative of the Department of Science and Innovation

National Research Foundation

South African Medical Research Council

National Research Foundation of South Africa

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

Link

https://academic.oup.com/jpids/article-pdf/11/7/341/45045142/piac018.pdf

Reference12 articles.