Social Determinants of Adherence to Treatment for Tuberculosis Infection and Disease Among Children, Adolescents, and Young Adults: A Narrative Review

Author:

Leddy Anna M12,Jaganath Devan123,Triasih Rina4,Wobudeya Eric5,Bellotti de Oliveira Marcia C6,Sheremeta Yana7,Becerra Mercedes C8,Chiang Silvia S910ORCID

Affiliation:

1. Division of Pulmonary and Critical Care Medicine, University of California, San Francisco , San Francisco, California , USA

2. Center for Tuberculosis, University of California, San Francisco , San Francisco, California , USA

3. Division of Pediatric Infectious Diseases, University of California, San Francisco , San Francisco, California , USA

4. Department of Pediatrics, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital , Yogyakarta , Indonesia

5. Mulago National Referral Hospital , Kampala , Uganda

6. Department of Pediatrics, Souza Marques Medical School , Rio de Janeiro , Brazil

7. All-Ukrainian Network of People Living With HIV/AIDS , Kyiv , Ukraine

8. Department of Global Health and Social Medicine, Harvard Medical School , Boston, Massachusetts , USA

9. Department of Pediatrics, Alpert Medical School of Brown University , Providence, Rhode Island , USA

10. Center for International Health Research, Rhode Island Hospital , Providence , Rhode Island , USA

Abstract

Abstract Global efforts to eliminate tuberculosis (TB) must address the unique barriers that children (ages 0 through 9 years) and adolescents/young adults (AYA; ages 10 through 24 years) face in adhering to treatment for TB infection and disease. We conducted a narrative review to summarize current knowledge on the social determinants of treatment adherence among these age groups to guide efforts and policy to address their unique needs. Our findings revealed that research on TB treatment adherence among children and AYA is still in its nascent stage. The current literature revealed structural/community-, health system-, household-, and individual-level factors that influence treatment adherence and varied with developmental stage. There is a need to develop multilevel interventions to address the unique challenges that children and AYA face in adhering to TB treatment.

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

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