Evaluation of a Live-Attenuated Human Parainfluenza Virus Type 2 Vaccine in Adults and Children-Reference-Cited by-同舟云学术

Evaluation of a Live-Attenuated Human Parainfluenza Virus Type 2 Vaccine in Adults and Children

Published:2023-01-03 Issue:3 Volume:12 Page:173-176
ISSN:2048-7207
Container-title:Journal of the Pediatric Infectious Diseases Society
language:en
Short-container-title:

Author:

Karron Ruth A¹,Herbert Kristi¹,Wanionek Kimberli¹,Schmidt Alexander C²³,Schaap-Nutt Anne²,Collins Peter L²,Buchholz Ursula J²

Affiliation:

1. Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland , USA

2. RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health , Bethesda, Maryland , USA

3. Bill & Melinda Gates Medical Research Institute Present Affiliation: , Cambridge, Massachusetts , USA

Abstract

Abstract We conducted a phase I clinical trial of the live-attenuated recombinant human parainfluenza virus type 2 (HPIV2) vaccine candidate rHPIV2-15C/948L/∆1724 sequentially in adults, HPIV2-seropositive children, and HPIV2-seronegative children, the target population for vaccination. rHPIV2-15C/948L/∆1724 was appropriately restricted in replication in adults and HPIV2-seropositive children but was overattenuated for HPIV2-seronegative children.

Funder

NIAID

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

Link

https://academic.oup.com/jpids/advance-article-pdf/doi/10.1093/jpids/piac137/48957022/piac137.pdf

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