Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Antibody Responses in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) and Mild and Severe Coronavirus Disease 2019 (COVID-19)-Reference-Cited by-同舟云学术

Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Antibody Responses in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) and Mild and Severe Coronavirus Disease 2019 (COVID-19)

Published:2020-12-02 Issue:5 Volume:10 Page:669-673
ISSN:2048-7207
Container-title:Journal of the Pediatric Infectious Diseases Society
language:en
Short-container-title:

Author:

Anderson Elizabeth M¹,Diorio Caroline²³,Goodwin Eileen C¹,McNerney Kevin O²³,Weirick Madison E¹,Gouma Sigrid¹,Bolton Marcus J¹,Arevalo Claudia P¹,Chase Julie²⁴,Hicks Philip¹⁵,Manzoni Tomaz B¹,Baxter Amy E⁶⁷,Andrea Kurt P⁶⁷,Burudpakdee Chakkapong²,Lee Jessica H²,Vella Laura A⁶⁷⁸,Henrickson Sarah E⁹,Harris Rebecca M¹⁰,Wherry E John⁶⁷,Bates Paul¹¹¹,Bassiri Hamid²⁸^ORCID,Behrens Edward M²⁴,Teachey David T²³,Hensley Scott E¹

Affiliation:

1. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

2. Immune Dysregulation Frontier Program, Department of Pediatrics, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

3. Department of Pediatrics, Division of Oncology, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

4. Department of Pediatrics, Division of Rheumatology, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

5. School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

6. Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

7. Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA

8. Department of Pediatrics, Division of Infectious Diseases, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

9. Department of Pediatrics, Division of Allergy and Immunology, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

10. Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

11. Penn Center for Research on Coronavirus and Other Emerging Pathogens, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

Abstract Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike immunoglobulin G (IgG) titers compared with those with severe coronavirus disease 2019, likely reflecting a longer time since the onset of infection in MIS-C patients.

Funder

University of Pennsylvania

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology, and Child Health

Link

http://academic.oup.com/jpids/advance-article-pdf/doi/10.1093/jpids/piaa161/34670371/piaa161.pdf

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