A Novel Lineage of Ceftriaxone-resistant Salmonella Typhi From India That Is Closely Related to XDR S. Typhi Found in Pakistan

Author:

Sah Ranjit12,Donovan Suzanne3,Seth-Smith Helena M B456,Bloemberg Guido7,Wüthrich Daniel456,Stephan Roger7,Kataria Sushila1,Kumar Mahadevan1,Singla Sonam1,Deswal Vikas1,Kaur Amarjeet1,Neumayr Andreas89,Hinic Vladimira45,Egli Adrian45,Kuenzli Esther8910

Affiliation:

1. Medanta The Medicity, Gurgaon, Haryana, India

2. Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal

3. UCLA Medical Center, Los Angeles, California, USA

4. Clinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland

5. Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland

6. Swiss Institute of Bioinformatics, Basel, Switzerland

7. National Reference Center for Enteropathogenic Bacteria and Listeria, Institute for Food Safety and Hygiene, University of Zurich, Zurich, Switzerland

8. Swiss Tropical and Public Health Institute, Basel, Switzerland

9. University of Basel, Basel, Switzerland

10. Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland

Abstract

Abstract Two MDR Salmonella Typhi isolates from India were found by whole genome sequencing to be closely related to the 2016 XDR S. Typhi outbreak strain from Pakistan. The Indian isolates have no chromosomal antimicrobial resistance cassette but carry the IncY plasmid p60006. Both isolates are susceptible to chloramphenicol, azithromycin, and carbapenems.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference14 articles.

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