Liver Fibrosis Progression and Mortality in Hepatitis B– and C–Coinfected Persons Treated With Directly Acting Antiviral Agents: Results From ERCHIVES-Reference-Cited by-同舟云学术

Liver Fibrosis Progression and Mortality in Hepatitis B– and C–Coinfected Persons Treated With Directly Acting Antiviral Agents: Results From ERCHIVES

Published:2019-12-16 Issue:3 Volume:71 Page:664-666
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Butt Adeel A¹²³,Yan Peng¹,Aslam Samia¹,Abou-Samra Abdul-Badi²³,Sherman Kenneth E⁴,Shaikh Obaid S¹

Affiliation:

1. VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA

2. Weill Cornell Medical College, New York, New York, USA, and Doha, Qatar

3. Hamad Medical Corporation, Doha, Qatar

4. University of Cincinnati School of Medicine, Cincinnati, Ohio, USA

Abstract

Abstract For persons with baseline Fibrosis-4 1.46–3.25, cirrhosis incidence/1000 patient-years was 49.3 among hepatitis B virus (HBV)/hepatitis C virus (HCV) coinfected and 18.2 among HCV monoinfected (P = .03). Cirrhosis risk was numerically higher but statistically nonsignificant among HBV/HCV coinfected (hazards ratio [HR] 1.51; 95% confidence intervals [CI], .37–6.05) but lower among those who attained sustained virologic response (HR, .52; 95% CI, .42–.63).

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciz1097/31538614/ciz1097.pdf

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