Loa loa Microfilariae in Skin Snips: Consequences for Onchocerciasis Monitoring and Evaluation in L. loa

Loa loa Microfilariae in Skin Snips: Consequences for Onchocerciasis Monitoring and Evaluation in L. loa–Endemic Areas

Published:2019-03-06 Issue:9 Volume:69 Page:1628-1630
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Nana-Djeunga Hugues C¹^ORCID,Fossuo-Thotchum Floribert¹,Pion Sébastien D²,Chesnais Cédric B²,Kubofcik Joseph³,Mackenzie Charles D⁴,Klion Amy D³,Boussinesq Michel²,Nutman Thomas B³,Kamgno Joseph¹⁵

Affiliation:

1. Centre for Research on Filariasis and Other Tropical Diseases, Yaounde, Cameroon

2. Institut de Recherche pour le Développement (IRD), Unité Mixte Internationale (UMI) 233-Institut National de la Santé et de la Recherche Médicale (INSERM) U1175, Montpellier University, France

3. Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

4. Neglected Tropical Diseases Support Center, Task Force for Global Health, Atlanta, Georgia

5. Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Cameroon

Abstract

Abstract The specificity of skin snips for onchocerciasis diagnoses is considered to be almost 100%. Our molecular methods revealed that microfilariae emerging from skin snips collected from highly microfilaremic Loa loa–infected individuals were largely misidentified as Onchocerca volvulus. This has important implications for onchocerciasis diagnostic testing in Loa-endemic areas.

Funder

Bill and Melinda Gates Foundation

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/article-pdf/69/9/1628/30145004/ciz172.pdf

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