RADIOPROTECTIVE EFFECT OF HYDROXYL RADICAL SCAVENGERS ON PROKARYOTIC AND EUKARYOTIC CELLS UNDER VARIOUS GAMMA IRRADIATION CONDITIONS-Reference-Cited by-同舟云学术

RADIOPROTECTIVE EFFECT OF HYDROXYL RADICAL SCAVENGERS ON PROKARYOTIC AND EUKARYOTIC CELLS UNDER VARIOUS GAMMA IRRADIATION CONDITIONS

Published:2019-12 Issue:2-3 Volume:186 Page:186-190
ISSN:0144-8420
Container-title:Radiation Protection Dosimetry
language:en
Short-container-title:

Author:

Ondrák Lukáš¹²,Vachelová Jana³,Davídková Marie³,Neužilová Barbora¹,Čuba Václav¹,Múčka Viliam¹

Affiliation:

1. Department of Nuclear Chemistry, Faculty of Nuclear Science and Physical Engineering, Czech Technical University in Prague, Prague 1 115 19, Czech Republic

2. Center of Nuclear Medicine, Prague 9 190 00 , Czech Republic

3. Department of Radiation Dosimetry, Institute of Nuclear Physics of the CAS, Prague 8 180 00, Czech Republic

Abstract

Abstract The influence of various hydroxyl radical scavengers such as methanol, ethanol and dimethyl sulfoxide on radiation sensitivity of prokaryotic cells (bacteria Escherichia coli) and eukaryotic cells (yeast Saccharomyces cerevisiae and V79 cells—Chinese hamster pulmonary fibroblasts) irradiated by 60Co gamma radiation was investigated. The dependence of radiation sensitivity on dose rate in range from 1.8 to 100 Gy h−1 was evaluated. Survival of cells irradiated by increasing dose rates was followed using clonogenic assay. Specific protective effect was found to be a nonmonotonous function of dose rate with typical maximum at the dose rate range from 50 to 55 Gy h−1 in all studied cell types.

Funder

Ministry of Youth

Sports and Education

Publisher

Oxford University Press (OUP)

Subject

Public Health, Environmental and Occupational Health,Radiology Nuclear Medicine and imaging,General Medicine,Radiation,Radiological and Ultrasound Technology

Link

http://academic.oup.com/rpd/article-pdf/186/2-3/186/32983563/ncz201.pdf

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