De Novo-Whole Genome Assembly of the Roborovski Dwarf Hamster (Phodopus roborovskii) Genome: An Animal Model for Severe/Critical COVID-19

Author:

Andreotti Sandro1ORCID,Altmüller Janine2,Quedenau Claudia3,Borodina Tatiana3,Nouailles Geraldine4,Teixeira Alves Luiz Gustavo5,Landthaler Markus56,Bieniara Maximilian1,Trimpert Jakob7,Wyler Emanuel5

Affiliation:

1. Department of Mathematics and Computer Science, Institute of Computer Science, Freie Universität Berlin , Takustr. 9, Berlin , Germany

2. Cologne Center for Genomics, University of Cologne , Cologne , Germany

3. Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine , Berlin , Germany

4. Department of Infectious Diseases and Respiratory Medicine, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin , Berlin , Germany

5. Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology , Berlin , Germany

6. IRI Life Sciences, Institute of Biology, Humboldt-Universität zu Berlin , Berlin , Germany

7. Institut für Virologie, Freie Universität Berlin , Berlin , Germany

Abstract

Abstract The Roborovski dwarf hamster Phodopus roborovskii belongs to the Phodopus genus, one of the seven within Cricetinae subfamily. Like other rodents such as mice, rats, or ferrets, hamsters can be important animal models for a range of diseases. Whereas the Syrian hamster from the genus Mesocricetus is now widely used as a model for mild-to-moderate coronavirus disease 2019, Roborovski dwarf hamster shows a severe-to-lethal course of disease upon infection with the novel human coronavirus severe acute respiratory syndrome coronavirus 2.

Funder

Project “Virological

Helmholtz Association's

Publisher

Oxford University Press (OUP)

Subject

Genetics,Ecology, Evolution, Behavior and Systematics

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4. Simulation of the clinical and pathological manifestations of coronavirus disease 2019 (COVID-19) in a golden Syrian hamster model: implications for disease pathogenesis and transmissibility;Chan;Clin Infect Dis.,2020

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