Cortical thickness abnormalities in patients with first episode psychosis: a meta-analysis of psychoradiologic studies and replication in an independent sample

Author:

Wen Keren1,Zhao Youjin12,Gong Qiyong123ORCID,Zhu Ziyu1,Li Qian1,Pan Nanfang1,Fu Shiqin1,Radua Joaquim456,Vieta Eduard47,Kumar Poornima89,Kemp Graham J10,Biswal Bharat B1112

Affiliation:

1. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China

2. Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu 610041, Sichuan, China

3. Functional and Molecular Imaging Key Laboratory of Sichuan Province, Chengdu 610041, Sichuan, China

4. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Mental Health Research Networking Center (CIBERSAM), Barcelona 08036, Catalonia, Spain

5. Centre for Psychiatric Research and Education, Department of Clinical Neuroscience, Karolinska Institutet, Solna 171-77, Stockholm, Sweden

6. Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London WC2R 2LS, UK

7. Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Barcelona 08036, Catalonia, Spain

8. Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont 02478, MA, USA

9. Department of Psychiatry, Harvard Medical School, Boston 02115, MA, USA

10. Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L69 3GE, UK

11. Department of Biomedical Engineering, New Jersey Institute of Technology, Newark 07102, NJ, USA

12. The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China

Abstract

Abstract Background Abnormalities of cortical thickness (CTh) in patients with their first episode psychosis (FEP) have been frequently reported, but findings are inconsistent. Objective To define the most consistent CTh changes in patients with FEP by meta-analysis of published whole-brain studies. Methods The meta-analysis used seed-based d mapping (SDM) software to obtain the most prominent regional CTh changes in FEP, and meta-regression analyses to explore the effects of demographics and clinical characteristics. The meta-analysis results were verified in an independent sample of 142 FEP patients and 142 age- and sex-matched healthy controls (HCs), using both a vertex-wise and a region of interest analysis, with multiple comparisons correction. Results The meta-analysis identified lower CTh in the right middle temporal cortex (MTC) extending to superior temporal cortex (STC), insula, and anterior cingulate cortex (ACC) in FEP compared with HCs. No significant correlations were identified between CTh alterations and demographic or clinical variables. These results were replicated in the independent dataset analysis. Conclusion This study identifies a robust pattern of cortical abnormalities in FEP and extends understanding of gray matter abnormalities and pathological mechanisms in FEP.

Funder

National Natural Science Foundation of China

National Institutes of Health

National Institute of Mental Health

China Postdoctoral Science Foundation

Sichuan University

Publisher

Oxford University Press (OUP)

Subject

General Medicine

Reference91 articles.

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