G1 is the major APOL1 risk allele for hypertension-attributed nephropathy in Central Africa

Author:

Sumaili Ernest K1,Shemer Revital2,Kruzel-Davila Etty23,Cohen Eric P4,Mutantu Pierre N5,Bukabau Justine B1,Makulo Jean Robert R1,Mokoli Vieux M1,Luse Jeannine L6,Pakasa Nestor M7,Cavalier Etienne8,Wumba Roger D9,Reiner-Benaim Anat10,Boner Geoffrey11,Lifschitz Meyer12,Nseka Nazaire M1,Skorecki Karl23,Wasser Walter G313ORCID

Affiliation:

1. Renal Unit, Department of Internal Medicine, Kinshasa University Hospital, University of Kinshasa, Kinshasa Democratic Republic of the Congo

2. Rappaport Faculty of Medicine and Research Institute, Technion - Israel Institute of Technology, Haifa, Israel

3. Division of Nephrology, Rambam Health Care Campus, Haifa, Israel

4. Nephrology Division, University of Maryland School of Medicine, Baltimore, MD, USA

5. Genetics Laboratory, Kinshasa University Hospital, University of Kinshasa, Kinshasa, Democratic Republic of the Congo

6. Renal Unit, Kinshasa Provincial General Hospital, Kinshasa, Democratic Republic of the Congo

7. Department of Pathology, Kinshasa University Hospital, University of Kinshasa, Democratic Republic of the Congo

8. Division of Clinical Chemistry, Centre Hospitalier Universitaire de Liege, University of Liege, Liège, Belgium

9. Department of Tropical Medicine, Kinshasa University Hospital, University of Kinshasa, Democratic Republic of the Congo

10. Clinical Epidemiology Unit, Rambam Health Care Campus, Haifa, Israel

11. Department of Medicine, Tel Aviv University Sackler Faculty of Medicine (retired), Tel Aviv University, Ramat Aviv, Israel

12. Division of Nephrology, Shaare Zedek Medical Center, Jerusalem, Israel

13. Division of Nephrology, Mayanei HaYeshua Medical Center, Bnei Brak, Israel

Funder

Froedtert Hospital Foundation

E.P.C.

Laboratory of University of Liege

E.C.

Rappaport Faculty of Medicine and Research Institute

Israel Science Foundation

Ernest and Bonnie Beutler Foundation

Kaylie Kidney Health Research Fund

Publisher

Oxford University Press (OUP)

Subject

Transplantation,Nephrology

Reference29 articles.

1. Association of trypanolytic APOL1 variants with kidney disease in African Americans;Genovese;Science,2010

2. Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene;Tzur;Hum Genet,2010

3. APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy;Kopp;J Am Soc Nephrol,2011

4. APOL1 risk variants are strongly associated with HIV-associated nephropathy in Black South Africans;Kasembeli;J Am Soc Nephrol,2015

5. Apolipoprotein L-I is the trypanosome lytic factor of human serum;Vanhamme;Nature,2003

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