Diversity of MHC class II <i>DRB</i> alleles in the Northern chamois genus <i>Rupicapra</i>-Reference-Cited by-同舟云学术

Diversity of MHC class II DRB alleles in the Northern chamois genus Rupicapra

Published:2024-02-12 Issue:2 Volume:105 Page:312-322
ISSN:0022-2372
Container-title:Journal of Mammalogy
language:en
Short-container-title:

Author:

Stipoljev Sunčica¹^ORCID,Buzan Elena²³^ORCID,Iacolina Laura¹²^ORCID,Safner Toni⁴,Rezić Andrea¹,Galov Ana⁵^ORCID,Križanović Krešimir⁶,Ambarlı Hüseyin⁷^ORCID,Arnal MariaCruz⁸^ORCID,Babaev Elmar⁹^ORCID,Bego Ferdinand¹⁰,Farkas Attila¹¹,Gačić Dragan¹²^ORCID,Lazar Peter¹³,Maletić Vladimir¹⁴,Markov Georgi¹⁵,Milošević Dragana¹⁶,Papaioannou Haritakis¹⁷,Scandura Massimo¹⁸^ORCID,Šprem Nikica¹

Affiliation:

1. Faculty of Agriculture, Department of Fisheries, Apiculture, Wildlife Management and Special Zoology, University of Zagreb , 10000 Zagreb , Croatia

2. Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska , 6000 Koper , Slovenia

3. Faculty of Environmental Protection , 3320 Velenje , Slovenia

4. Faculty of Agriculture, Department of Plant Breeding, Genetics and Biometrics, University of Zagreb , 10000 Zagreb , Croatia

5. Faculty of Science, Department of Biology, University of Zagreb , 10000 Zagreb , Croatia

6. Faculty of Electrical Engineering and Computing, Department of Electronic Systems and Information Processing, University of Zagreb , 10000 Zagreb , Croatia

7. Department of Wildlife Ecology and Management, Düzce University , 81010 Düzce , Turkey

8. Facultad de Veterinaria, Departamento de Patología Animal, Universidad de Zaragoza , 50002 Zaragoza , Spain

9. Precaspian Institute of Biological Resources of the Dagestan Federal Research Centre of the Russian Academy of Sciences , 367000 Makhachkala , Russia

10. Faculty of Natural Sciences, Department of Biology, University of Tirana , 1000 Tirana , Albania

11. Faculty of Technical and Human Sciences, Sapientia Hungarian University of Transylvania , 540003 Târgu-Mureș , Romania

12. Faculty of Forestry, University of Belgrade , 11000 Belgrade , Serbia

13. Department for Breeding and Disease of Game and Fish, University of Veterinary Medicine and Pharmacy , 04000 Košice , Slovakia

14. Faculty of Forestry, Ss. Cyril and Methodius University , 1000 Skopje, North Macedonia

15. Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences , 1000 Sofia , Bulgaria

16. Faculty of Sciences and Mathematics, Department of Biology, University of Montenegro , 80000 Podgorica , Montenegro

17. Department of Biological Applications and Technology, Biodiversity Conservation Lab, University of Ioannina , 45221 Ioannina , Greece

18. Department of Veterinary Medicine, University of Sassari , 07100 Sassari , Italy

Abstract

Abstract Major histocompatibility complex (MHC) genes are commonly used markers for monitoring adaptive genetic and evolutionary potential of species. In this study, we investigated genetic variation of the MHC class II DRB locus in the chamois genus Rupicapra by using next-generation sequencing. Sequencing of 102 samples led to the identification of 25 alleles, 11 of which are novel. The high ratio of the relative rates of nonsynonymous to synonymous mutations (dN/dS) suggests a signal of positive selection on this locus. We analyzed patterns of genetic variation within and among 2 subspecies of Northern Chamois and compared them to previously published studies using neutral markers to provide a basis for assessing the effects of demographic processes. Our analyses have shown that alleles are likely to be maintained by balancing selection in different populations with similar frequencies and that this mechanism also works in small, isolated populations that are strongly affected by genetic drift.

Funder

Croatian Science Foundation

Slovenian Research Agency

RESBIOS European Union’s Horizon 2020 Research and Innovation Program

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/jmammal/article-pdf/105/2/312/57193508/gyae008.pdf

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