The wide spectrum of COVID-19 neuropsychiatric complications within a multidisciplinary centre
Author:
Delorme Cécile12, Houot Marion134, Rosso Charlotte156, Carvalho Stéphanie1, Nedelec Thomas17ORCID, Maatoug Redwan18, Pitron Victor89, Gassama Salimata2, Sambin Sara12ORCID, Bombois Stéphanie3, Herlin Bastien1011, Ouvrard Gaëlle12, Bruneteau Gaëlle213, Hesters Adèle2, Gales Ana Zenovia14ORCID, Millet Bruno18, Lamari Foudil15, Lehericy Stéphane116, Navarro Vincent121017, Rohaut Benjamin12ORCID, Demeret Sophie2, Maisonobe Thierry217, Yger Marion18, Degos Bertrand19, Mariani Louise-Laure12, Bouche Christophe8, Dzierzynski Nathalie20, Oquendo Bruno21, Ketz Flora22, Nguyen An-Hung23, Kas Aurélie24, Lubetzki Catherine12, Delattre Jean-Yves1, Corvol Jean-Christophe12, Delorme Cecile, Corvol Jean-Christophe, Delattre Jean-Yves, Carvalho Stephanie, Sagnes Sandrine, Dubois Bruno, Navarro Vincent, Louapre Celine, Stojkovic Tanya, Idbaih Ahmed, Rosso Charlotte, Grabli David, Gales Ana Zenovia, Millet Bruno, Rohaut Benjamin, Bayen Eleonore, Dupont Sophie, Bruneteau Gaelle, Lehericy Stephane, Seilhean Danielle, Durr Alexandra, Lamari Foudil, Brochard Vanessa Batista, Lubetzki Catherine, Pradat-Diehl Pascale, Hoang-Xuan Khe, Fontaine Bertrand, Naccache Lionel, Fossati Philippe, Arnulf Isabelle, Carpentier Alexandre, Edel Yves, Robain Gilberte, Thoumie Philippe, Degos Bertrand, Sharshar Tarek, Alamowitch Sonia, Apartis-Bourdieu Emmanuelle, Peretti Charles-Siegried, Ursu Renata, Dzierzynski Nathalie, Bourron Kiyoka Kinugawa, Belmin Joel, Oquendo Bruno, Pautas Eric, Verny Marc, Samson Yves, Leder Sara, Leger Anne, Deltour Sandrine, Baronnet Flore, Bombois Stephanie, Touat Mehdi, Sanson Marc, Dehais Caroline, Houillier Caroline, Laigle-Donadey Florence, Psimaras Dimitri, Alenton Agusti, Younan Nadia, Villain Nicolas, del Mar Amador Maria, Mariani Louise-Laure, Mezouar Nicolas, Mangone Graziella, Meneret Aurelie, Hartmann Andreas, Tarrano Clement, Bendetowicz David, Pradat Pierre-François, Baulac Michel, Sambin Sara, Pichit Phintip, Chochon Florence, Hesters Adele, Herlin Bastien, Nguyen An Hung, Porcher Valerie, Demoule Alexandre, Morawiec Elise, Mayaux Julien, Faure Morgan, Ewenczyk Claire, Coarelli Giulia, Heinzmann Anna, Masingue Marion, Bassez Guillaume, An Isabelle, Worbe Yulia, Lambrecq Virginie, Debs Rabab, Musat Esteban Munoz, Lenglet Timothee, Lambrecq Virginie, Hanin Aurelie, Chougar Lydia, Shor Nathalia, Pyatigorskaya Nadya, Galanaud Damien, Leclercq Delphine, Demeret Sophie, Cao Albert, Marois Clemence, Weiss Nicolas, Gassama Salimata, Le Guennec Loic, Degos Vincent, Jacquens Alice, Similowski Thomas, Morelot-Panzini Capucine, Rotge Jean-Yves, Saudreau Bertrand, Pitron Victor, Sarni Nassim, Girault Nathalie, Maatoug Redwan, Leu Smaranda, Thivard Lionel, Mokhtari Karima, Plu Isabelle, Gonçalves Bruno, Bottin Laure, Yger Marion, Ouvrard Gaelle, Haddad Rebecca, Ketz Flora, Lafuente Carmelo, Oasi Christel, Megabarne Bruno, Herve Dominique, Salman Haysam, Rametti-Lacroux Armelle, Chalançon Alize, Herve Anais, Royer Hugo, Beauzor Florence, Maheo Valentine, Laganot Christelle, Minelli Camille, Fekete Aurelie, Grine Abel, Biet Marie, Hilab Rania, Besnard Aurore, Bouguerra Meriem, Goudard Gwen, Houairi Saida, Al-Youssef Saba, Pires Christine, Oukhedouma Anissa, Siuda-Krzywicka Katarzyna, Malkinson Tal Seidel, Agguini Hanane, Said Safia, Houot Marion,
Affiliation:
1. CNRS UMR 7225, Sorbonne Université, Paris Brain Institute—ICM, Inserm U1127, Paris 75013, France 2. Département de Neurologie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France 3. Département de Neurologie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Institut de la Mémoire et de la maladie d’Alzheimer, Paris 75013, France 4. Centre of Excellence of Neurodegenerative Disease (CoEN), Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France 5. Urgences cérébro-Vasculaires, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France 6. Paris Brain Institute—ICM Stroke Network, STAR Team, Pitié-Salpêtrière Hospital, Paris 75013, France 7. INRIA, Aramis Project-Team, Paris 75013, France 8. Service de Psychiatrie adulte, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France 9. Institut Jean-Nicod, UMR 8129, ENS/EHESS/CNRS, IEC, PSL Research University, Paris 75005, France 10. Département de Neurologie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Unité d’épileptologie, Paris 75013, France 11. Département de Médecine Physique et de réadaptation, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié Salpêtrière Hospital, Paris 75013, France 12. Service de Neuro-orthopédie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Rothschild Hospital, Paris 75012, France 13. Centre de Recherche en Myologie, UMRS974, Association Institut de Myologie, Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Paris 75013, France 14. Service des Pathologies du sommeil, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France 15. Département de Biochimie Métabolique, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France 16. Département de Neuroradiologie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France 17. Département de Neurophysiologie Clinique, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France 18. Unité de Soins intentifs neurovasculaires, Assistance Publique Hôpitaux de Paris, Sorbonne Université Saint-Antoine Hospital, Paris 75012, France 19. Département de Neurologie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Avicenne Hospital, Bobigny 93000, France 20. Département de Psychiatrie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Tenon Hospital, Paris 75020, France 21. Service de Gériatrie à orientation neurologique, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Charles Foix Hospital, Paris 94200, France 22. Service de Gériatrie polyvalente, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Charles Foix Hospital, Paris 94200, France 23. Service d’Addictologie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière, Paris 75013, France 24. Service de Médecine Nucléaire et LIB, INSERM U1146, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié- Salpêtrière Hospital, Paris 75013, France
Abstract
Abstract
A variety of neuropsychiatric complications has been described in association with COVID-19 infection. Large scale studies presenting a wider picture of these complications and their relative frequency are lacking. The objective of our study was to describe the spectrum of neurological and psychiatric complications in patients with COVID-19 seen in a multidisciplinary hospital centre over 6 months. We conducted a retrospective, observational study of all patients showing neurological or psychiatric symptoms in the context of COVID-19 seen in the medical and university neuroscience department of Assistance Publique Hopitaux de Paris—Sorbonne University. We collected demographic data, comorbidities, symptoms and severity of COVID-19 infection, neurological and psychiatric symptoms, neurological and psychiatric examination data and, when available, results from CSF analysis, MRI, EEG and EMG. A total of 249 COVID-19 patients with a de novo neurological or psychiatric manifestation were included in the database and 245 were included in the final analyses. One-hundred fourteen patients (47%) were admitted to the intensive care unit and 10 (4%) died. The most frequent neuropsychiatric complications diagnosed were encephalopathy (43%), critical illness polyneuropathy and myopathy (26%), isolated psychiatric disturbance (18%) and cerebrovascular disorders (16%). No patients showed CSF evidence of SARS-CoV-2. Encephalopathy was associated with older age and higher risk of death. Critical illness neuromyopathy was associated with an extended stay in the intensive care unit. The majority of these neuropsychiatric complications could be imputed to critical illness, intensive care and systemic inflammation, which contrasts with the paucity of more direct SARS-CoV-2-related complications or post-infection disorders.
Funder
Fondation de France
Publisher
Oxford University Press (OUP)
Subject
General Earth and Planetary Sciences,General Environmental Science
Cited by
19 articles.
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