Integrative approach of omics and imaging data to discover new insights for understanding brain diseases

Author:

Yoon Jong Hyuk1ORCID,Lee Hagyeong1,Kwon Dayoung1,Lee Dongha2,Lee Seulah1,Cho Eunji1,Kim Jaehoon1,Kim Dayea3

Affiliation:

1. Neurodegenerative Diseases Research Group, Korea Brain Research Institute , Daegu 41062 , Republic of Korea

2. Cognitive Science Research Group, Korea Brain Research Institute , Daegu 41062 , Republic of Korea

3. New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub) , Daegu 41061 , Republic of Korea

Abstract

Abstract Treatments that can completely resolve brain diseases have yet to be discovered. Omics is a novel technology that allows researchers to understand the molecular pathways underlying brain diseases. Multiple omics, including genomics, transcriptomics and proteomics, and brain imaging technologies, such as MRI, PET and EEG, have contributed to brain disease-related therapeutic target detection. However, new treatment discovery remains challenging. We focused on establishing brain multi-molecular maps using an integrative approach of omics and imaging to provide insights into brain disease diagnosis and treatment. This approach requires precise data collection using omics and imaging technologies, data processing and normalization. Incorporating a brain molecular map with the advanced technologies through artificial intelligence will help establish a system for brain disease diagnosis and treatment through regulation at the molecular level.

Funder

Korea Brain Research Institute

Ministry of Science and Information and Communication Technology

National Research Foundation of Korea

Korean Government

Publisher

Oxford University Press (OUP)

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