The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal
Author:
Publisher
Oxford University Press (OUP)
Subject
Genetics(clinical),Genetics,Molecular Biology,General Medicine
Link
http://academic.oup.com/hmg/article-pdf/22/7/1383/1604874/dds554.pdf
Reference67 articles.
1. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
2. Secondary Structure of Huntingtin Amino-Terminal Region
3. Kinase inhibitors modulate huntingtin cell localization and toxicity
4. Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity
5. The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis
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1. Huntingtin is an RNA binding protein and participates in NEAT1 -mediated paraspeckles;Science Advances;2024-07-19
2. Fluorescent protein tagging promotes phase separation and alters the aggregation pathway of huntingtin exon-1;Journal of Biological Chemistry;2024-01
3. Huntingtin Interacting Proteins and Pathological Implications;International Journal of Molecular Sciences;2023-08-22
4. IKBKB reduces huntingtin aggregation by phosphorylating serine 13 via a non-canonical IKK pathway;Life Science Alliance;2023-08-08
5. Ubiquitin-modifying enzymes in Huntington’s disease;Frontiers in Molecular Biosciences;2023-02-08
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