Chloroquine Versus Dihydroartemisinin-Piperaquine With Standard High-dose Primaquine Given Either for 7 Days or 14 Days in Plasmodium vivax Malaria

Author:

Chu Cindy S12,Phyo Aung Pyae1,Turner Claudia12,Win Htun Htun1,Poe Naw Pet1,Yotyingaphiram Widi1,Thinraow Suradet1,Wilairisak Pornpimon1,Raksapraidee Rattanaporn1,Carrara Verena I1,Paw Moo Kho1,Wiladphaingern Jacher1,Proux Stéphane1,Bancone Germana12,Sriprawat Kanlaya1,Lee Sue J23,Jeeyapant Atthanee3,Watson James23,Tarning Joel23,Imwong Mallika34,Nosten François12,White Nicholas J23

Affiliation:

1. Shoklo Malaria Research Unit, Mahidol–Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand

2. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom

3. Mahidol–Oxford Tropical Medicine Research Unit

4. Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Abstract

Chloroquine or dihydroartemisinin-piperaquine with either 7- or 14-day primaquine regimens provided highly effective radical cure of vivax malaria on the Thailand-Myanmar border. Short course higher dose primaquine regimens for vivax malaria radical cure may improve efficacy by improving adherence.

Funder

Wellcome Trust

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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