Therapeutic Trial of Rifabutin After Rifampicin-Associated DRESS Syndrome in Tuberculosis-Human Immunodeficiency Virus Coinfected Patients

Author:

Lehloenya Rannakoe J.12,Dlamini Sipho3,Muloiwa Rudzani4,Kakande Betty1,Ngwanya Mzudumile R.1,Todd Gail1,Dheda Keertan2

Affiliation:

1. Division of Dermatology

2. Lung Infection and Immunity Unit

3. Division of Infectious Disease and HIV Medicine, Department of Medicine

4. Department of Paediatrics and Child Health, University of Cape Town, South Africa

Abstract

Abstract Elimination of a rifamycin from the treatment regimen for tuberculosis negatively impacts outcomes. Cross-reactivity between the rifamycins after drug eruptions is unclear. We report 6 consecutive human immunodeficiency virus-infected patients with rifampicin-associated drug rash with eosinophilia and systemic symptoms (DRESS) syndrome confirmed on diagnostic rechallenge. The patients subsequently tolerated rifabutin. These data inform clinical management of tuberculosis-associated drug reactions.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Reference17 articles.

1. Tuberculosis;Dheda;Lancet,2016

2. Global tuberculosis report 2015: World Health Organization;World Health Organization,2015

3. Cutaneous adverse drug reactions to anti-tuberculosis drugs: state of the art and into the future;Lehloenya;Expert Rev Anti Infect Ther,2012

4. Drug reaction with eosinophilia and systemic symptoms (DRESS): a clinical update and review of current thinking;Walsh;Clin Exp Dermatol,2011

5. Outcomes of reintroducing anti-tuberculosis drugs following cutaneous adverse drug reactions;Lehloenya;Int J Tuberc Lung Dis,2011

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