Liquid Chromatographic Approaches to Antibiotic Residue Analysis

Abstract

Abstract Liquid chromatography has been widely used for determination of antibiotics and other drugs In formulations and in biological fluids for clinical tests. Application to residue analysis is more difficult because of the need for higher sensitivity and isolation from complex biological substrates. Numerous LC methods for chloramphenicol and sulfonamides have been described. LC methods are beginning to be described for residues of other antibiotics. Several approaches have been used for extraction of residues from food substrates. Residues have been cleaned up and concentrated by using partitioning and/or solid-phase extraction. With some residues, cleanup and analysis can be done In the LC system. LC offers considerable potential for rapid, automated residue analysis.