1. Medizinische Klinik III, University Hospital of Heidelberg , Im Neuenheimer Feld 410, 69120 Heidelberg , Germany
2. BHF Centre for Cardiovascular Science, University of Edinburgh , Edinburgh , UK
3. Usher Institute, University of Edinburgh , Edinburgh , UK
4. Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel , Basel , Switzerland