1. Departments of Cardiology and Laboratory Medicine and Pathology, Mayo Clinic , 200 First St SW, Rochester, MN 55905 , USA
2. BHF Centre for Cardiovascular Science, University of Edinburgh , Edinburgh , UK
3. Usher Institute, University of Edinburgh , Edinburgh , UK
4. Cardiovascular Research Institute Basel (CRIB), Department of Cardiology, University Hospital Basel, University of Basel , Basel , Switzerland