1. Departments of Cardiology and Laboratory Medicine and Pathology, Mayo Clinic , 200 First St SW, Rochester, MN 55905 , USA
2. BHF Centre for Cardiovascular Sciences, University of Edinburgh, SU.226 Chancellor's Building, Royal Infirmary of Edinburgh , 49 Little France Crescent, Edinburgh EH16 4SU , UK
3. Usher Institute, University of Edinburgh , 9 Little France Road, Edinburgh BioQuarter, Edinburgh EH16 4UX , UK
4. Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel , Petersgraben 4, CH-4031 Basel , Switzerland