HALL: a comprehensive database for human aging and longevity studies

Author:

Li Hao12,Wu Song342ORCID,Li Jiaming12,Xiong Zhuang5ORCID,Yang Kuan126,Ye Weidong78,Ren Jie1269,Wang Qiaoran12,Xiong Muzhao12,Zheng Zikai12,Zhang Shuo12,Han Zichu12,Yang Peng12,Jiang Beier7,Ping Jiale12,Zuo Yuesheng12,Lu Xiaoyong12,Zhai Qiaocheng7,Yan Haoteng1011,Wang Si101112,Ma Shuai132912,Zhang Bing1,Ye Jinlin7,Qu Jing14215912,Yang Yun-Gui126,Zhang Feng8,Liu Guang-Hui132159101112ORCID,Bao Yiming342,Zhang Weiqi126912ORCID

Affiliation:

1. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation , Beijing 100101 , China

2. University of Chinese Academy of Sciences , Beijing 100049 , China

3. CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation , Beijing 100101 , China

4. National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation , Beijing 100101 , China

5. Interdisciplinary Institute for Medical Engineering, Fuzhou University , Fuzhou 350002 , China

6. Sino-Danish College, University of Chinese Academy of Sciences , Beijing 101408 , China

7. Department of Vascular Surgery, Quzhou Affiliated Hospital of Wenzhou Medical University, Beijing 100101 , China

8. The Joint Innovation Center for Engineering in Medicine, Quzhou Affiliated Hospital of Wenzhou Medical University , 324000 , China

9. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences , Beijing 100101 , China

10. Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University , Beijing 100053 , China

11. Aging Translational Medicine Center, Xuanwu Hospital, Capital Medical University , Beijing 100053 , China

12. Aging Biomarker Consortium , Beijing 100101 , China

13. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101 , China

14. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101 , China

15. Beijing Institute for Stem Cell and Regenerative Medicine , Beijing 100101 , China

Abstract

Abstract Diverse individuals age at different rates and display variable susceptibilities to tissue aging, functional decline and aging-related diseases. Centenarians, exemplifying extreme longevity, serve as models for healthy aging. The field of human aging and longevity research is rapidly advancing, garnering significant attention and accumulating substantial data in recent years. Omics technologies, encompassing phenomics, genomics, transcriptomics, proteomics, metabolomics and microbiomics, have provided multidimensional insights and revolutionized cohort-based investigations into human aging and longevity. Accumulated data, covering diverse cells, tissues and cohorts across the lifespan necessitates the establishment of an open and integrated database. Addressing this, we established the Human Aging and Longevity Landscape (HALL), a comprehensive multi-omics repository encompassing a diverse spectrum of human cohorts, spanning from young adults to centenarians. The core objective of HALL is to foster healthy aging by offering an extensive repository of information on biomarkers that gauge the trajectory of human aging. Moreover, the database facilitates the development of diagnostic tools for aging-related conditions and empowers targeted interventions to enhance longevity. HALL is publicly available at https://ngdc.cncb.ac.cn/hall/index.

Funder

National Key Research and Development Program of China

Strategic Priority Research Program of the Chinese Academy of Sciences

Quzhou Technology Projects

National Natural Science Foundation of China

CAS Project for Young Scientists in Basic Research

Program of the Beijing Natural Science Foundation

Informatization Plan of Chinese Academy of Sciences

New Cornerstone Science Foundation

Youth Innovation Promotion Association of CAS

Excellent Young Talents Program of Capital Medical University

Project for Technology Development of Beijing-affiliated Medical Research Institutes

Young Elite Scientists Sponsorship Program by CAST

Excellent Young Talents Training Program for the Construction of Beijing Municipal University Teacher Team

Publisher

Oxford University Press (OUP)

Subject

Genetics

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