1. Department of Investigative Medicine, Graduate School of Medicine, University of the Ryukyus , Nishihara-cho, Okinawa 903-0215 , Japan
2. Department of Dermatology, Graduate School of Medicine, University of the Ryukyus , Nishihara-cho, Okinawa 903-0215 , Japan
3. Department of Biochemistry, Graduate School of Medicine, University of the Ryukyus , Nishihara-cho, Okinawa 903-0215 , Japan