Occupational exposures and odds of gastric cancer: a StoP project consortium pooled analysis-Reference-Cited by-同舟云学术

Occupational exposures and odds of gastric cancer: a StoP project consortium pooled analysis

Published:2020-01-21 Issue:2 Volume:49 Page:422-434
ISSN:0300-5771
Container-title:International Journal of Epidemiology
language:en
Short-container-title:

Author:

Shah Shailja C¹^ORCID,Boffetta Paolo²,Johnson Kenneth C³,Hu Jinfu⁴,Palli Domenico⁵,Ferraroni Monica⁶,Tsugane Shoichiro⁷^ORCID,Hamada Gerson Shigueaki⁸,Hidaka Akihisa⁷,Zaridze David⁹,Maximovich Dmitry⁹,Vioque Jesus¹⁰¹¹,Navarrete-Munoz Eva M¹⁰¹¹,Zhang Zuo-Feng¹²,Mu Lina¹³,Boccia Stefania¹⁴¹⁵,Pastorino Roberta¹⁵,Kurtz Robert C¹⁶,Rota Matteo⁶¹⁷¹⁸,Bonzi Rossella⁶,Negri Eva¹⁹,La Vecchia Carlo⁶,Pelucchi Claudio⁶,Hashim Dana²

Affiliation:

1. Gastroenterology, Hepatology and Nutrition, Vanderbilt University School of Medicine, Nashville, TN, USA

2. Tisch Cancer Institute, Department of Hematology and Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

3. School of Epidemiology and Public Health, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada

4. Harbin Medical University, Harbin, China

5. Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy

6. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

7. Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Japan

8. Nikkei Disease Prevention Center, São Paulo, Brazil

9. Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia

10. CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain

11. Department of Public Health, Miguel Hernandez University, FISABIO-ISABIAL, Campus San Juan, Alicante, Spain

12. Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA

13. Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA

14. Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy

15. Section of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore, Roma, Italy

16. Department of Medicine, Memorial Sloan Kettering Cancer Centre, New York, NY, USA

17. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

18. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

19. Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy

Abstract

Abstract Background Gastric cancer pathogenesis represents a complex interaction of host genetic determinants, microbial virulence factors and environmental exposures. Our primary aim was to determine the association between occupations/occupational exposures and odds of gastric cancer. Methods We conducted a pooled-analysis of individual-level data harmonized from 11 studies in the Stomach cancer Pooling Project. Multivariable logistic regression was used to estimate the odds ratio (OR) of gastric cancer adjusted for relevant confounders. Results A total of 5279 gastric cancer cases and 12 297 controls were analysed. There were higher odds of gastric cancer among labour-related occupations, including: agricultural and animal husbandry workers [odds ratio (OR) 1.33, 95% confidence interval (CI): 1.06–1.68]; miners, quarrymen, well-drillers and related workers (OR 1.70, 95% CI: 1.01–2.88); blacksmiths, toolmakers and machine-tool operators (OR 1.41, 95% CI: 1.05–1.89); bricklayers, carpenters and construction workers (OR 1.30, 95% CI: 1.06–1.60); and stationary engine and related equipment operators (OR 6.53, 95% CI: 1.41–30.19). The ORs for wood-dust exposure were 1.51 (95% CI: 1.01–2.26) for intestinal-type and 2.52 (95% CI: 1.46–4.33) for diffuse-type gastric cancer. Corresponding values for aromatic amine exposure were 1.83 (95% CI: 1.09–3.06) and 2.92 (95% CI: 1.36–6.26). Exposure to coal derivatives, pesticides/herbicides, chromium, radiation and magnetic fields were associated with higher odds of diffuse-type, but not intestinal-type gastric cancer. Conclusions Based on a large pooled analysis, we identified several occupations and related exposures that are associated with elevated odds of gastric cancer. These findings have potential implications for risk attenuation and could be used to direct investigations evaluating the impact of targeted gastric cancer prevention/early detection programmes based on occupation.

Funder

Associazione Italiana per la Ricerca sul Cancro

AIRC

Italian Ministry of Health

Publisher

Oxford University Press (OUP)

Subject

General Medicine,Epidemiology

Link

http://academic.oup.com/ije/article-pdf/49/2/422/33338099/dyz263.pdf

Reference44 articles.

1. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries;Bray;CA Cancer J Clin,2018