EpiMetal: an open-source graphical web browser tool for easy statistical analyses in epidemiology and metabolomics-Reference-Cited by-同舟云学术

EpiMetal: an open-source graphical web browser tool for easy statistical analyses in epidemiology and metabolomics

Published:2020-01-16 Issue:4 Volume:49 Page:1075-1081
ISSN:0300-5771
Container-title:International Journal of Epidemiology
language:en
Short-container-title:

Author:

Ekholm Jussi¹²³,Ohukainen Pauli¹²³,Kangas Antti J⁴,Kettunen Johannes¹²³⁵,Wang Qin¹²³⁶,Karsikas Mari¹²³⁷,Khan Anmar A⁸⁹,Kingwell Bronwyn A¹⁰,Kähönen Mika¹¹,Lehtimäki Terho¹²,Raitakari Olli T¹³¹⁴,Järvelin Marjo-Riitta²³¹⁵¹⁶¹⁷,Meikle Peter J⁸,Ala-Korpela Mika¹²³⁶¹⁸^ORCID

Affiliation:

1. Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland

2. Biocenter Oulu, Oulu, Finland

3. Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland

4. Nightingale Health Ltd, Helsinki, Finland

5. THL: National Institute for Health and Welfare, Helsinki, Finland

6. Systems Epidemiology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia

7. Solita Ltd, Tampere, Finland

8. Metabolomics, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia

9. Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia

10. Metabolic and Vascular Physiology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia

11. Department of Clinical Physiology, Tampere University Hospital and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

12. Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

13. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

14. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland

15. Unit of Primary Health Care, Oulu University Hospital, OYS, Oulu, Finland

16. Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, Imperial College London, London, UK

17. Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK

18. NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland

Abstract

Abstract Motivation An intuitive graphical interface that allows statistical analyses and visualizations of extensive data without any knowledge of dedicated statistical software or programming. Implementation EpiMetal is a single-page web application written in JavaScript, to be used via a modern desktop web browser. General features Standard epidemiological analyses and self-organizing maps for data-driven metabolic profiling are included. Multiple extensive datasets with an arbitrary number of continuous and category variables can be integrated with the software. Any snapshot of the analyses can be saved and shared with others via a www-link. We demonstrate the usage of EpiMetal using pilot data with over 500 quantitative molecular measures for each sample as well as in two large-scale epidemiological cohorts (N >10 000). Availability The software usage exemplar and the pilot data are open access online at [http://EpiMetal.computationalmedicine.fi]. MIT licensed source code is available at the Github repository at [https://github.com/amergin/epimetal].

Funder

Senior Research Fellowship

National Health and Medical Research Council

NHMRC

University of Bristol

UK Medical Research Council

Novo Nordisk Foundation

Sigrid Juselius Foundation

Academy of Finland

Publisher

Oxford University Press (OUP)

Subject