Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: a pilot study-Reference-Cited by-同舟云学术

Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: a pilot study

Published:2013-03 Issue:3 Volume:15 Page:277-283
ISSN:1388-9842
Container-title:European Journal of Heart Failure
language:en
Short-container-title:European Journal of Heart Failure

Author:

Maron Bradley A.¹²,Opotowsky Alexander R.³²,Landzberg Michael J.³,Loscalzo Joseph⁴,Waxman Aaron B.⁴⁵²,Leopold Jane A.⁴

Affiliation:

1. Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and the Department of Cardiology, Veterans Affairs Boston Healthcare System, West Roxbury; MA USA

2. The Dyspnea Center at Brigham and Women's Hospital; Boston MA USA

3. Boston Adult Congenital Heart Program, Department of Cardiology; Children's Hospital Boston; MA USA

4. Division of Cardiovascular Medicine, Department of Medicine; Brigham and Women's Hospital; Boston MA USA

5. Division of Pulmonary and Critical Care Medicine, Department of Medicine; Brigham and Women's Hospital and Harvard Medical School; Boston MA USA

Publisher

Wiley

Subject

Cardiology and Cardiovascular Medicine

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1093/eurjhf/hfs173/fullpdf

Reference32 articles.

1. Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells;Maron;J Biol Chem,2009

2. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity;Leopold;Nat Med,2007

3. Aldosterone in congestive heart failure;Weber;N Engl J Med,2001

4. The effect of spironolactone on morbidity and mortality in patients with severe heart failure: Randomized Aldactone Evaluation Study Investigators;Pitt;N Eng J Med,1999

5. Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide level and modulate pulmonary arterial hypertension;Maron;Circulation,2012

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