IsoXpressor: A Tool to Assess Transcriptional Activity within Isochores-Reference-Cited by-同舟云学术

IsoXpressor: A Tool to Assess Transcriptional Activity within Isochores

Published:2020-08-28 Issue:9 Volume:12 Page:1573-1578
ISSN:1759-6653
Container-title:Genome Biology and Evolution
language:en
Short-container-title:

Author:

Ayad Lorraine A K¹^ORCID,Dourou Athanasia-Maria²,Arhondakis Stilianos²,Pissis Solon P³⁴

Affiliation:

1. Department of Informatics, King’s College London, United Kingdom

2. Bioinformatics and Computational Science (BioCoS), Chania, Greece

3. CWI, Amsterdam, The Netherlands

4. Vrije Universiteit, Amsterdam, The Netherlands

Abstract

AbstractGenomes are characterized by large regions of homogeneous base compositions known as isochores. The latter are divided into GC-poor and GC-rich classes linked to distinct functional and structural properties. Several studies have addressed how isochores shape function and structure. To aid in this important subject, we present IsoXpressor, a tool designed for the analysis of the functional property of transcription within isochores. IsoXpressor allows users to process RNA-Seq data in relation to the isochores, and it can be employed to investigate any biological question of interest for any species. The results presented herein as proof of concept are focused on the preimplantation process in Homo sapiens (human) and Macaca mulatta (rhesus monkey).

Publisher

Oxford University Press (OUP)

Subject

Genetics,Ecology, Evolution, Behavior and Systematics

Link

http://academic.oup.com/gbe/advance-article-pdf/doi/10.1093/gbe/evaa171/33693730/evaa171.pdf

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