Vertebrate Lineages Exhibit Diverse Patterns of Transposable Element Regulation and Expression across Tissues

Author:

Pasquesi Giulia I M12,Perry Blair W1,Vandewege Mike W3ORCID,Ruggiero Robert P4,Schield Drew R15,Castoe Todd A1

Affiliation:

1. Department of Biology, University of Texas at Arlington

2. Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder

3. Department of Biology, Eastern New Mexico University

4. Department of Biology, Southeast Missouri State University

5. Department of Ecology and Evolutionary Biology, University of Colorado, Boulder

Abstract

Abstract Transposable elements (TEs) comprise a major fraction of vertebrate genomes, yet little is known about their expression and regulation across tissues, and how this varies across major vertebrate lineages. We present the first comparative analysis integrating TE expression and TE regulatory pathway activity in somatic and gametic tissues for a diverse set of 12 vertebrates. We conduct simultaneous gene and TE expression analyses to characterize patterns of TE expression and TE regulation across vertebrates and examine relationships between these features. We find remarkable variation in the expression of genes involved in TE negative regulation across tissues and species, yet consistently high expression in germline tissues, particularly in testes. Most vertebrates show comparably high levels of TE regulatory pathway activity across gonadal tissues except for mammals, where reduced activity of TE regulatory pathways in ovarian tissues may be the result of lower relative germ cell densities. We also find that all vertebrate lineages examined exhibit remarkably high levels of TE-derived transcripts in somatic and gametic tissues, with recently active TE families showing higher expression in gametic tissues. Although most TE-derived transcripts originate from inactive ancient TE families (and are likely incapable of transposition), such high levels of TE-derived RNA in the cytoplasm may have secondary, unappreciated biological relevance.

Funder

University of Texas at Arlington

Society for the Study of Evolution

Publisher

Oxford University Press (OUP)

Subject

Genetics,Ecology, Evolution, Behavior and Systematics

Reference101 articles.

1. The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes;Abrieu;J Cell Sci,2001

2. Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system;Agrawal;Nature,1998

3. Differential expression analysis for sequence count data;Anders;Genome Biol,2010

4. The Piwi–piRNA pathway provides an adaptive defense in the transposon arms race;Aravin;Science,2007

5. Identification and characterization of small RNAs involved in RNA silencing;Aravin;FEBS Lett,2005

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