The 6-hydroxychromanol derivative SUL-109 ameliorates renal injury after deep hypothermia and rewarming in rats

Author:

Vogelaar Pieter C12ORCID,Roorda Maurits1,de Vrij Edwin L1,Houwertjes Martin C3,Goris Maaike1,Bouma Hjalmar14,van der Graaf Adrianus C2,Krenning Guido25,Henning Robert H1

Affiliation:

1. Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

2. Sulfateq B.V., Groningen, The Netherlands

3. Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

4. Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

5. Cardiovascular Regenerative Medicine, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Funder

Innovative Action Program Groningen

Samenwerkingsverband Noord Nederland

EFRO Tender Valorization

Groningen University Institute for Drug Exploration

Innovational Research Incentive

Netherlands Organization for Health Research and Development

Publisher

Oxford University Press (OUP)

Subject

Transplantation,Nephrology

Reference40 articles.

1. Mitochondrial dysfunction in the pathophysiology of renal diseases;Che;Am J Physiol Renal Physiol,2014

2. Persistent disruption of mitochondrial homeostasis after acute kidney injury;Funk;Am J Physiol Renal Physiol,2012

3. Hypothermia and kidney: a focus on ischaemia–reperfusion injury;De Rosa;Nephrol Dial Transplant,2017

4. Age changes of mitochondria of rat kidney;Sato;Mech Ageing Dev,1982

5. Pathways of glutathione metabolism and transport in isolated proximal tubular cells from rat kidney;Visarius;Biochem Pharmacol,1996

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