The role of xanthine dioxygenase in the biosynthetic pathway of 2-aza-8-oxohypoxanthine of<i>Lepista sordida</i>-Reference-Cited by-同舟云学术

The role of xanthine dioxygenase in the biosynthetic pathway of 2-aza-8-oxohypoxanthine ofLepista sordida

Published:2023-01-18 Issue:4 Volume:87 Page:420-425
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Kotajima Mihaya¹,Choi Jae-Hoon¹²³⁴⁵^ORCID,Suzuki Tomohiro⁵⁶^ORCID,Wu Jing³⁵,Hirai Hirofumi¹²³⁴⁵,Nelson David C⁷,Ouchi Hitoshi⁸,Inai Makoto⁸,Dohra Hideo²⁴⁵,Kawagishi Hirokazu³⁵

Affiliation:

1. Graduate School of Science and Technology, Shizuoka University , 836 Ohya, Suruga-ku, Shizuoka, Japan

2. Graduate School of Integrated Science and Technology, Shizuoka University , 836 Ohya, Suruga-ku, Shizuoka, Japan

3. Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, Japan

4. Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, Japan

5. Research Institute for Mushroom Science, Shizuoka University , 836 Ohya, Suruga-ku, Shizuoka , Japan

6. Center for Bioscience Research and Education, Utsunomiya University , 350 Mine-machi, Utsunomiya, Tochigi , Japan

7. Department of Botany and Plant Sciences, University of California , Riverside, CA , USA

8. School of Pharmaceutical Sciences, University of Shizuoka , 52-1 Yada, Suruga-ku, Shizuoka , Japan

Abstract

ABSTRACT2-Azahypoxanthine (AHX) and 2-aza-8-oxohypoxanthine (AOH), discovered as causal substances of fairy rings are known to be endogenous in the fairy ring-forming Lepista sordida. In this study, we showed that xanthine dioxygenase, an a-ketoglutarate-dependent dioxygenase, might catalyze the conversion of AHX to AOH in the fungus. Furthermore, this enzyme is the first reported molybdopterin-independent protein of hypoxanthine metabolism.

Funder

JSPS

Institute for Fermentation, Osaka

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbad005/49133861/zbad005.pdf

Reference21 articles.

1. Plant-growth regulator, imidazole-4-carboxamide, produced by the fairy ring forming fungus Lepista sordida;Choi;J Agric Food Chem,2010

2. Disclosure of the “fairy” of fairy ring-forming fungus Lepista sordida;Choi;ChemBioChem,2010

3. Bioconversion of AHX to AOH by resting cells of Burkholderia contaminans CH-1;Choi;Biosci Biotechnol Biochem,2016

4. High-quality draft genome sequence of Burkholderia contaminans CH-1, a gram-negative bacterium that metabolizes 2-azahypoxanthine, a plant growth-regulating compound;Choi;Genome Announc,2017

5. Draft genome sequence of buttiauxella sp. A111 that converts 2-azahypoxanthine to 2-aza-8-oxohypoxanthine;Choi;Microbiol Res Announc,2019