Mouse TMC4 is involved in the detection of chloride taste of salts-Reference-Cited by-同舟云学术

Mouse TMC4 is involved in the detection of chloride taste of salts

Published:2023-11-08 Issue:2 Volume:88 Page:203-205
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Narukawa Masataka¹,Masago Aya¹,Murata Momo¹,Saito Yoshikazu²³,Kasahara Yoichi²,Abe Keiko²,Asakura Tomiko²⁴

Affiliation:

1. Department of Food and Nutrition, Kyoto Women's University , Kyoto City, Kyoto , Japan

2. Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo City, Tokyo , Japan

3. Research Department, Toyo Institute of Food Technology , Kawanishi City, Hyogo , Japan

4. Department of Liberal Arts, The Open University of Japan , Chiba City, Chiba , Japan

Abstract

Abstract Licking behavior with various salts in transmembrane channel-like 4 (Tmc4) knockout (KO) mice was observed. In Tmc4 KO mice, a significant decrease in sensitivity to chloride salts, such as NaCl, KCl, and NH4Cl, was observed, while no significant decrease in sensitivity to Na-gluconate was observed. This finding suggests that TMC4 may be involved in the detection of chloride taste.

Funder

Grant-in-Aid for Scientific Research

Challenging Research Exploratory

Salt Science Research Foundation

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbad155/53479389/zbad155.pdf

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