Long-term intake of α-glycerophosphocholine (GPC) suppresses microglial inflammation and blood-brain barrier (BBB) disruption and promotes neurogenesis in senescence-accelerated mice prone 8 (SAMP8)-Reference-Cited by-同舟云学术

Long-term intake of α-glycerophosphocholine (GPC) suppresses microglial inflammation and blood-brain barrier (BBB) disruption and promotes neurogenesis in senescence-accelerated mice prone 8 (SAMP8)

Published:2023-09-18 Issue:12 Volume:87 Page:1537-1542
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Umino Mitsuki¹,Okuda Mayumi²,Ohkubo Takeshi³,Fujii Tsutomu⁴,Matsubara Kiminori¹²

Affiliation:

1. Department of Human Life Science Education, Graduate School of Humanities and Social Sciences, Hiroshima University , Higashi-Hiroshima, Hiroshima , Japan

2. Department of Human Life Science Education, Graduate School of Education, Hiroshima University , Higashi-Hiroshima, Hiroshima , Japan

3. Department of Health Nutrition , Sendai Shirayuri Women's College, Sehndai, Miyagi , Japan

4. Faculty of Food and Agricultural Sciences, Fukushima University , Fukushima , Japan

Abstract

ABSTRACT We evaluated the effects of long-term glycerophosphocholine (GPC) intake on microglia, the blood-brain barrier (BBB), and neurogenesis in senescence-accelerated mice prone 8 (SAMP8). The GPC intake suppressed microglial activation and BBB disruption and sustained doublecortin-positive cells in the hippocampus. The results indicate that GPC intake exerts anti-inflammatory and neuroprotective effects in the brain of aged mice.

Funder

Council for Science, Technology and Innovation

SIP

JSPS

Kieikai Research Foundation

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbad135/51820602/zbad135.pdf

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