Safety evaluation and maximum use level for transient ingestion in humans of allitol
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Published:2023-06-24
Issue:10
Volume:87
Page:1193-1204
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ISSN:1347-6947
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Container-title:Bioscience, Biotechnology, and Biochemistry
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language:en
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Short-container-title:
Author:
Miyoshi Miku12, Yoshihara Akihide1, Mochizuki Susumu1, Kato Shiro1, Yoshida Hiromi3, Matsuo Tatsuhiro1, Kishimoto Yuka4, Inazu Tadao5, Kimura Isao2, Izumori Ken1, Akimitsu Kazuya1
Affiliation:
1. Faculty of Agriculture and International Institute of Rare Sugar Research and Education, Kagawa University , Miki, Kagawa 761-0795 , Japan 2. Fermentation & Food Research Institute, Kagawa Prefectural Industrial Technology Research Center, Shodoshima , Shozu, Kagawa 761-4421 , Japan 3. Faculty of Medicine and International Institute of Rare Sugar Research and Education, Kagawa University , Miki, Kagawa 761-0793 , Japan 4. Research Laboratory, Matsutani Chemical Industry Co., Ltd. , Itami, Hyogo 664-8508 , Japan 5. Food Research Institute, Kagawa Prefectural Industrial Technology Research Center, Goto , Takamatsu, Kagawa 761-8031 , Japan
Abstract
ABSTRACT
Allitol is a hexitol produced by reducing the rare sugar D-allulose with a metal catalyst under hydrogen gas. To confirm the safe level of allitol, we conducted a series of safety assessments. From the results of Ames mutagenicity assay using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537, Escherichia coli strain WP2uvrA, and an in vitro chromosomal aberration test on cultured Chinese hamster cells, allitol did not show any significant genotoxic effect. No significant effects on general condition, urinalysis, hematology, physiology, histopathology, or at necropsy were observed at a dose of 1500 mg/kg body weight of allitol in the acute and 90-day subchronic oral-toxicity assessments for rats. A further study performed on healthy adult humans showed that the acute use level of allitol for diarrhea was 0.2 g/kg body weight for both men and women. The results of current safety assessment studies suggest that allitol is safe for human consumption.
Funder
Ministry of Education, Culture, Sports, Science and Technology
Publisher
Oxford University Press (OUP)
Subject
Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology
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