Estimating telomere length from whole genome sequence data-Reference-Cited by-同舟云学术

Estimating telomere length from whole genome sequence data

Published:2014-03-07 Issue:9 Volume:42 Page:e75-e75
ISSN:1362-4962
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Ding Zhihao¹,Mangino Massimo²,Aviv Abraham³,Spector Tim²,Durbin Richard¹,

Affiliation:

1. Genome Informatics, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK

2. Department of Twin Research and Genetic Epidemiology, King's College London, London, WC2R 2LS, UK

3. The Center for Human Development and Aging, New Jersey Medical School, Rutgers University, Newark, NJ 07103, USA

Abstract

Abstract Telomeres play a key role in replicative ageing and undergo age-dependent attrition in vivo. Here, we report a novel method, TelSeq, to measure average telomere length from whole genome or exome shotgun sequence data. In 260 leukocyte samples, we show that TelSeq results correlate with Southern blot measurements of the mean length of terminal restriction fragments (mTRFs) and display age-dependent attrition comparably well as mTRFs.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

http://academic.oup.com/nar/article-pdf/42/9/e75/38713544/gku181.pdf

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