Monotherapy with either dolutegravir or raltegravir fails to durably suppress HIV viraemia in humanized mice-Reference-Cited by-同舟云学术

Monotherapy with either dolutegravir or raltegravir fails to durably suppress HIV viraemia in humanized mice

Published:2017-06-13 Issue:9 Volume:72 Page:2570-2573
ISSN:0305-7453
Container-title:Journal of Antimicrobial Chemotherapy
language:en
Short-container-title:

Author:

Heredia Alonso¹,Hassounah Said²,Medina-Moreno Sandra¹,Zapata Juan C.¹,Le Nhut M.¹,Han Yingshan²,Foulke James S.¹,Davis Charles¹,Bryant Joseph¹,Redfield Robert R.¹,Wainberg Mark A.²

Affiliation:

1. Institute of Human Virology, University of Maryland School of Medicine, Medicine, Baltimore, MD, USA

2. McGill University AIDS Centre, Lady Davis Institute, Montréal, Quebec, Canada

Funder

Canadian Institutes of Health Research

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology,Microbiology (medical)

Link

http://academic.oup.com/jac/article-pdf/72/9/2570/24332466/dkx195.pdf

Reference20 articles.

1. Once-daily dolutegravir versus twice-daily raltegravir in antiretroviral-naive adults with HIV-1 infection (SPRING-2 study): 96 week results from a randomised, double-blind, non-inferiority trial;Raffi;Lancet Infect Dis,2013

2. Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1 integrase-DNA complexes;Hightower;Antimicrob Agents Chemother,2011

3. Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure;Mesplede;Retrovirology,2013

4. Resistance mutations against dolutegravir in HIV integrase impair the emergence of resistance against reverse transcriptase inhibitors;Oliveira;AIDS,2014

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