A new peptaibol, RK-026A, from the soil fungus Trichoderma sp. RK10-F026 by culture condition-dependent screening-Reference-Cited by-同舟云学术

A new peptaibol, RK-026A, from the soil fungus Trichoderma sp. RK10-F026 by culture condition-dependent screening

Published:2021-01 Issue:1 Volume:85 Page:69-76
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Rawa Mira Syahfriena Amir¹²^ORCID,Nogawa Toshihiko¹^ORCID,Okano Akiko¹,Futamura Yushi¹^ORCID,Nakamura Takemichi³,Wahab Habibah A²^ORCID,Osada Hiroyuki¹^ORCID

Affiliation:

1. Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan

2. School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia

3. Molecular Structure Characterization Unit, RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan

Abstract

Abstract A new peptaibol, RK-026A (1) was isolated from a fungus, Trichoderma sp. RK10-F026, along with atroviridin B (2), alamethicin II (3), and polysporin B (4) as a cytotoxic compound, which was selected by principal component analysis of the MS data from 5 different culture conditions. The structure of 1 was determined as a new atroviridin B derivative containing Glu at the 18th residue instead of Gln by NMR and HR-MS analyses including the investigation of detailed MS/MS fragmentations. 1 showed cytotoxicity toward K562 leukemia cells at an IC50 value of 4.1 µm.

Funder

JSPS

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/85/1/69/36669341/zbaa051.pdf

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