Affiliation:
1. Graduate School of Agricultural Science, Tohoku University, Aramaki Aza-Aoba, Aoba-ku, Sendai, Japan
Abstract
Abstract
Indole diterpenoids constitute a large family of natural products that are characterized by a hybrid molecular architecture consisting of an indole nucleus and diterpenoid moiety. Their pharmacologically and agriculturally important biological properties as well as intriguing molecular architectures have attracted much attention from many synthetic organic chemists. In 2012, we succeeded in the concise total synthesis of a paspalane-type indole diterpenoid, namely paspalinine, by developing a highly efficient indole ring formation protocol. After the report of this total synthesis, 4 research groups achieved the total syntheses of other paspalane- and nodulisporane-type indole diterpenoids using current state-of-the-art methods. This review summarizes the total syntheses of the paspalane- and nodulisporane-type indole diterpenoids that were described in the last 10 years.
Funder
Japan Society for the Promotion of Science
Publisher
Oxford University Press (OUP)
Subject
Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology
Reference61 articles.
1. Tremorgenic and nontremorgenic 2,3-fused indole diterpenoids;Sings,2003
2. Selective removal of the N-BOC protective group using silica gel at low pressure;Apelqvist;Tetrahedron Lett,1996
3. Synthesis of (±)-lecanindole D;Asanuma;Tetrahedron Lett,2013
4. A new class of easily activated palladium precatalysts for facile C-N cross-coupling reactions and the low temperature oxidative addition of aryl chlorides;Biscoe;J Am Chem Soc,2008
5. Preparation of indole diterpene alkaloids as Maxi-K channel blockers for the treatment of glaucoma;Brnardic,2009
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献