Vector design for enhancing expression level and assembly of knob-into-hole based FabscFv-Fc bispecific antibodies in CHO cells
Author:
Affiliation:
1. Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR) , 20 Biopolis Way, #06-01 Centros, Singapore 138668, Singapore
Abstract
Funder
Biomedical Research Council
Agency for Science, Technology and Research
Singapore and Bioprocessing Technology Institute
Publisher
Oxford University Press (OUP)
Subject
Immunology,Immunology and Allergy
Link
https://academic.oup.com/abt/advance-article-pdf/doi/10.1093/abt/tbac025/46958173/tbac025.pdf
Reference35 articles.
1. Design and production of bispecific antibodies;Wang;Antibodies,2019
2. Biology drives the discovery of bispecific antibodies as innovative therapeutics;Nie;Antib Ther,2020
3. Production of bispecific antibodies in “knobs-into-holes” using a cell-free expression system;Xu;MAbs,2015
4. Engineering bispeci fi c antibodies with de fi ned chain pairing;Krah;N Biotechnol,2017
5. An efficient route to human bispecific IgG;Merchant;Nat Biotechnol,1998
Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Design and engineering of bispecific antibodies: insights and practical considerations;Frontiers in Bioengineering and Biotechnology;2024-01-25
2. Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies;mAbs;2023-07-04
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