RORγt+Foxp3+ regulatory T cells in the regulation of autoimmune arthritis

Author:

Furuyama Kotona1,Kondo Yuya1,Shimizu Masaru1,Yokosawa Masahiro1,Segawa Seiji1,Iizuka Akira1,Tanimura Reona1,Tsuboi Hiroto1,Matsumoto Isao1,Sumida Takayuki1

Affiliation:

1. Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan

Abstract

Abstract RORγt+Foxp3+regulatory T (Treg) cells, known as T regulatory 17 cells (Tr17 cells), are a novel subset of Treg cells, which have the potential to regulate the development of experimental autoimmune encephalomyelitis (EAE) thorough a specific repression of T helper 17 (Th17) cell-mediated inflammation. However, the function of Tr17 cells the development of other autoimmune diseases such as autoimmune arthritis remains unclear. Collagen-induced arthritis (CIA) was found to be prolonged in Foxp3creRORγtfl/fl mice, in which Tr17 cells were deleted, compared with Foxp3wtRORγtfl/fl mice. Tr17 cells were significantly increased in ankle joints (AJ) compared with draining lymph nodes after the onset of arthritis. CC chemokine receptor 6 (CCR6) was up-regulated on Tr17 cells compared to RORγt negative Treg cells. CD25, cytotoxic T-lymphocyte antigen 4 (CTLA-4), glucocorticoid-induced TNF-receptor (GITR), and inducible T-cell co-stimulator (ICOS) expression was also up-regulated on Tr17 cells compared to RORγt negative Treg cells. IL-10-producing cells and Blimp-1+ and T-bet+ cells were increased in Tr17 cells compared to RORγt-negative Treg cells. Tr17-enriched Treg cells significantly suppressed proliferation of conventional T cells through IL-10 compared with CCR6-Treg cells. Tr17 cells increased during the clinical course of CIA and accumulated in inflamed joints. Taken together, it appears that Tr17 cells play a crucial role in the regulation of autoimmune arthritis.

Funder

Japan Society for the Promotion of Science

AbbVie GK Research

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

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